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Epithelial root sheath
The Hertwig epithelial root sheath (HERS) or epithelial root sheath is a proliferation of epithelial cells located at the cervical loop of the enamel organ in a developing tooth. Hertwig epithelial root sheath initiates the formation of dentin in the root of a tooth by causing the differentiation of odontoblasts from the dental papilla. The root sheath eventually disintegrates with the periodontal ligament, but residual pieces that do not completely disappear are seen as epithelial cell rests of Malassez (ERM).〔Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 166〕 These rests can become cystic, presenting future periodontal infections.〔
==History of HERS==
Hertwig epithelial root sheath was not discovered in any mammalian species. Instead this epithelial structure was discovered by Oskar Hertwig in 1874 in an amphibian (see notes below for further discussion in other animals).〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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